Plant-derived substances such as curcumin and trans-resveratrol, both of which\nhave anti-inflammatory properties, may have a beneficial effect on human\nskin. The present study analyzed the effects of topical formulations containing\ncurcumin or trans-resveratrol on the recovery and rejuvenation of skin after\nchemical peeling. The study was performed on rats, randomly divided into\nseven groups of six animals each. Superficial peeling was performed using a\n50% glycolic acid gel, which was applied to the dorsal region of each animal.\nRats were then treated with the experimental formulations for 15 days. On the\nsixteenth day, skin samples were taken and mounted on slides for histological\nanalysis. Statistical analysis showed that the formulation containing transresveratrol\nled to increased dermal and epidermal thickness, while the formulation\ncontaining curcumin had no effects on epidermal thickness. The increased\nepidermal thickness may reflect greater skin vitality, although this was\nnot directly evaluated. The increase in dermal thickness may be attributed to\ngreater collagen production, which may increase skin firmness and elasticity,\nand lead to skin rejuvenation as well as wrinkle reduction. Formulations containing\ncurcumin or trans-resveratrol may have potential for the topical treatment\nafter peeling and of sensitive skin, in addition to being used for their antiaging\nproperties.
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